Salmonella (沙門氏桿菌) (要和Shigella比較):侵犯血液淋巴(因為有鞭毛)
只有人有,在小腸
- attach to the mucosa of small intestine and invade into the M (microfold) cells
- type III secretion systems
invasion into the intestinal mucosa (Salmonella pathogenicity island 1 [SPI-1]) and subsequent systemic disease (SPI-2)
- intracellular replication in the phagosome
- Protected from stomach acids and the acid pH of the phagosome by an acid tolerance response (ATR) gene
- eating contaminated food
- Direct fecal-oral (adapted to human)
- Highly adapted to humans can survive in the gallbladder (膽囊)
- Replicate after being transported to the liver, spleen, and bone marrow
- Typhoid fever (傷寒) (在 developing country) (Typhoid Mary)
- Enteric fever (腸熱症)
S. typhi produce a febrile illness called typhoid fever (傷寒)