衷醫行樂

Salmonella (沙門氏桿菌) (要和Shigella比較)：侵犯血液淋巴(因為有鞭毛)

只有人有，在小腸

• attach to the mucosa of small intestine and invade into the M (microfold) cells
• type III secretion systems

invasion into the intestinal mucosa (Salmonella pathogenicity island 1 [SPI-1]) and subsequent systemic disease (SPI-2)

• intracellular replication in the phagosome
• Protected from stomach acids and the acid pH of the phagosome by an acid tolerance response (ATR) gene
• eating contaminated food
• Direct fecal-oral (adapted to human)

• Highly adapted to humans can survive in the gallbladder (膽囊)
• Replicate after being transported to the liver, spleen, and bone marrow
• Typhoid fever (傷寒) (在 developing country) (Typhoid Mary)
• Enteric fever (腸熱症)

S. typhi produce a febrile illness called typhoid fever (傷寒)